什麼事

1. • What's up? Is something the matter?
2. • (used in rhetorical questions of the form 关 guān + {person} + 什么事 shénmeshì "what business is it of {person}'s?; what's it to {person}?")

     coll.

Character by character

• 什(shén)what
• 麼(me)suffix, used to form interrogative 什么 shénme, what?, indefinite 这么 zhème thus, etc
• 事(shì)matter