哀莫大於心死
Simplified:
哀莫大于心死
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nothing sadder than a withered heart (idiom attributed to Confucius by Zhuangzi 庄子 zhuāngzǐ)
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no greater sorrow than a heart that never rejoices
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the worst sorrow is not as bad as an uncaring heart
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nothing is more wretched than apathy
Character by character
Sources